Dataset from: Clinicopathological correlation of kidney disease in HIV infection pre- and post- ART rollout: VERSION 2

<p dir="ltr">This dataset comprises longitudinal data collected over a 25-year period (from 1989 to 2014). It covers the periods prior to and post Antiretroviral therapy (ART) initiation. The data is extracted from research of the subset of patients who were HIV positive and underwent a renal biopsy of their native kidney. Data from included patients was anonymized prior to statistical analysis.</p><p dir="ltr">Renal biopsies were performed at the two tertiary hospitals in Johannesburg on HIV-positive individuals, from January 1989 to December 2014 and were retrospectively analyzed. Demographic data (age, sex and race), clinical parameters (CD4 count, HIV viral load, serum creatinine and urine protein creatinine ratio), indication for biopsy and renal histological pattern was recorded at time of kidney biopsy. The estimated glomerular filtration rate (eGFR) was calculated according to the CKD-EPI creatinine equation without ethnicity correction. ART rollout began in April 2004 in South Africa. </p><p dir="ltr">Patients were divided into 2 groups - those who were biopsied pre-ART rollout and those biopsied post-ART rollouts. These two groups were compared with respect to the above parameters. In a subgroup of the patients biopsied between 2004 and 2014, additional data laboratory parameters (serum hemoglobin, serum albumin, serial serum creatinine and eGFR) and ART use (at time of biopsy) were recorded. All renal biopsies were processed according to standard techniques for light microscopy, immunofluorescence and electron microscopy. All biopsies were reviewed by the National Health Laboratory Service histopathology team who were aware of the HIV status of the patient at time of biopsy.<br>Histological diagnoses were tabulated using the 2018 Kidney Disease Improving Global Outcomes (KDIGO) Controversies Conference guidelines. As per this guideline FSGS (NOS) in the setting of HIV describes all non-collapsing forms of FSGS. Those ICGN with no identifiable comparative etiology other than HIV were categorized as uncharacterized ICGN with no etiology other than HIV. The biopsies with multiple diagnoses were assigned its major clinical-pathological diagnosis for the purposes of analysis.</p><p dir="ltr"><br></p>