posted on 2025-03-11, 08:06authored byNasiru Muhammad, Kennedy Erlwanger, Kasimu Ghandi Ibrahim
<p dir="ltr">This dataset presents the 21-day old weaned male Sprague-Dawley rats. They were received and terminated in batches. Each batch spent ten weeks of intervention before it was terminated.These rats(n=50) were randomized to six treatment groups (n=8-9) with unlimited access to commercial rat feed. Either plain water (C) or 20% fructose solution (Fr) were provided to drink. 400 mg.kg-1 M. oleifera methanolic leaf extract (Mo) or 100 mg.kg-1 fenofibrate were also administered daily for ten weeks. Growth, circulating metabolites, visceral and epididymal fat pads mass, hepatic lipids and general health markers were assessed.Liver samples were histologically examined using H&E stain. Analysis of the data was done with GraphPad Prism 5.0v for windows (GraphPad Software, Inc. CA), and the data were expressed as mean ± standard deviation and analysed by means of a one-way analysis of variance (ANOVA). Statistical significance was considered at P < 0.05.</p>